Which two are non-anticoagulant rodenticides?

Which two are non-anticoagulant rodenticides?

• A. Zinc phosphate and Bromethalin
• B. Warfarin and Diphenacone
• C. Bromadiolone and Difethialone
• D. Cholecalciferol and Warfarin

Answer: (A)

Non-anticoagulant rodenticides work through mechanisms other than inhibiting vitamin K–dependent clotting factors. Zinc phosphate (zinc phosphide) reacts in the stomach to release phosphine gas, causing rapid systemic toxicity, while Bromethalin acts as a neurotoxin by uncoupling oxidative phosphorylation in brain mitochondria, leading to swelling and neurological signs. Anticoagulant rodenticides, in contrast, disrupt blood clotting by inhibiting the vitamin K cycle, and examples include warfarin and several second-generation agents like bromadiolone and difethialone. Among the options, the two non-anticoagulants are zinc phosphate and bromethalin, making them the correct pair. The other choices mix anticoagulants with non-anticoagulants, which is why they’re not the right pair.

Non-anticoagulant rodenticides work through mechanisms other than inhibiting vitamin K–dependent clotting factors. Zinc phosphate (zinc phosphide) reacts in the stomach to release phosphine gas, causing rapid systemic toxicity, while Bromethalin acts as a neurotoxin by uncoupling oxidative phosphorylation in brain mitochondria, leading to swelling and neurological signs. Anticoagulant rodenticides, in contrast, disrupt blood clotting by inhibiting the vitamin K cycle, and examples include warfarin and several second-generation agents like bromadiolone and difethialone. Among the options, the two non-anticoagulants are zinc phosphate and bromethalin, making them the correct pair. The other choices mix anticoagulants with non-anticoagulants, which is why they’re not the right pair.